The term 'struggle with' can be defined by four crossword solutions: GRAPPLE (7 letters), CONTEND (7 letters), COPE (4 letters), and tiltat (6 letters). GRAPPLE means to engage in a close fight or struggle, while CONTEND means to strive in opposition or against difficulties. COPE means to deal effectively with something difficult, and tiltat means to engage in a dispute or contest. All of these words describe the act of struggling with something, whether it be an opponent, a difficult situation, or a dispute.