The crossword solution for the term ST. __, MO is Louis. St. Louis, Missouri is a major city located on the western bank of the Mississippi River. It is the second-largest city in the state and the largest metropolitan area in Missouri. St. Louis is known for its iconic Gateway Arch, which stands at 630 feet tall and is the tallest man-made monument in the United States. The city is also home to several professional sports teams, including the St. Louis Cardinals baseball team and the St. Louis Blues hockey team.