The crossword solution for the term ST. ___, MISSOURI is LOUIS. St. Louis, Missouri is a major city located in the eastern part of the state. It is the second largest city in Missouri and the 18th largest city in the United States. St. Louis is known for its iconic Gateway Arch, which is the tallest man-made monument in the United States. The city is also home to several professional sports teams, including the St. Louis Cardinals baseball team and the St. Louis Blues hockey team. St. Louis is a major cultural center, with numerous museums, theaters, and other attractions.