Spike and Pinky are two characters from the popular cartoon series 'Animaniacs'. They are a pair of bumbling mice who often get into trouble. Spike is the brains of the duo, while Pinky is the more naive one. The crossword solution for SPIKE AND PINKY is LEES, which is an acronym for the phrase 'Laughing Evenly Every Second'. This phrase is often used to describe the comedic antics of Spike and Pinky.