The term Spanish Queen can be represented by three crossword solutions: ENA (3 letters), ISABELLA (8 letters), and REINA (5 letters). ENA is a shortened form of the name Isabella, which was the name of a 15th century Spanish queen. Isabella was the Queen of Castile and León from 1474 to 1504 and is known for her role in the unification of Spain. Reina is the Spanish word for queen. Therefore, all three solutions refer to the same person, Isabella of Castile, who was a Spanish queen in the 15th century.