The term 'Slayer Vampire' refers to a character from popular culture who is tasked with the job of killing vampires. The crossword solution for this term is 'STAKE', which is a weapon used to kill vampires. A STAKE is typically made of wood and is used to pierce the heart of a vampire, thus killing them. This weapon has been used in many vampire-related stories and films, making it an iconic symbol of vampire slaying.