The crossword solution for the term 'Skunk River State' is Iowa, which is a four-letter word. Iowa is a state located in the Midwestern United States. It is bordered by six states: Wisconsin to the northeast, Illinois to the east, Missouri to the south, Nebraska to the west, South Dakota to the northwest, and Minnesota to the north. The Skunk River is a tributary of the Des Moines River that runs through the state of Iowa.