Signum is a Latin word meaning 'SIGN' or 'MARK'. It is often used in the context of a signature, as a SIGN of agreement or approval. In the context of a crossword puzzle, Signum could refer to a specific answer or clue that needs to be filled in. ECCE is the four-letter answer to the Signum clue, and it is an abbreviation for the Latin phrase 'ECCE Homo', which translates to 'Behold the Man'. This phrase is often used in Christian contexts to refer to Jesus Christ.