The crossword solutions for the term SIGNIFICANT ONE are OTHER, which is a five-letter word. OTHER is an English pronoun that is used to refer to a person or thing that is different from the ONE already mentioned or known about. It is often used to refer to a person or thing that is not specified or identified. OTHER can also be used to refer to a person or thing that is not important or SIGNIFICANT. In this case, the term SIGNIFICANT ONE is referring to someone or something that is important or has significance.