Severe depression, also known as MELANCHOLIA (11 letters), is a serious mental health disorder characterized by persistent feelings of sadness, emptiness, and hopelessness. It can lead to a variety of physical and emotional problems and can decrease a person's ability to function at work and at home. Symptoms of severe depression can include changes in appetite, sleep disturbances, fatigue, difficulty concentrating, and thoughts of suicide. Treatment for severe depression typically includes a combination of psychotherapy, medication, and lifestyle changes.