Setbacks are events or occurrences that impede progress or cause difficulty. The term can be broken down into five different crossword solutions: reverses (8 letters), LOSSES (6 letters), REVERSALS (9 letters), lapses (6 letters), and jolts (5 letters). Reverses refer to a change of direction or a reversal of fortune, while LOSSES refer to a decrease in value or amount. REVERSALS are a complete change in direction or opinion, and lapses are a temporary failure or decline. Finally, jolts refer to a sudden shock or surprise.