The term 'set loose' can be defined as releasing something from a state of confinement or restriction. This can be accomplished by using words such as 'UNTIE, ' 'FREE, ' 'FREED, ' 'unpen, ' 'UNHAND, ' and 'UNBRIDLE.' The first word, 'UNTIE, ' has five letters and means to undo the knots of something that is tied up. The second word, 'FREE, ' has four letters and means to release from captivity or restraint. The third word, 'FREED, ' also has five letters and is the past tense of the word 'FREE.' The fourth word, 'unpen, ' has five letters and means to open something that is closed or confined. The fifth word, 'UNHAND, ' has six letters and means to remove one's hand from something. The sixth word, 'UNBRIDLE, ' has eight letters and means to remove a bridle from an animal, thus allowing it to move freely.