The answer to the crossword for the term 'Second-Largest U.S. State' is TEX, which stands for Texas. Texas is the second largest state in the United States by both land area and population. It is located in the south-central region of the country and is bordered by Mexico, New Mexico, Oklahoma, Arkansas, and Louisiana. Texas is known for its diverse geography, ranging from desert and mountain regions to coastal plains and forests. It is also home to a variety of industries, including oil and gas, agriculture, and technology.