The second-largest lake in North America is Lake Huron, which has an area of 59, 596 square miles and is located on the border between Canada and the United States. It is the fifth-largest freshwater lake in the world and is part of the Great Lakes system. It is connected to Lake Michigan through the Straits of Mackinac and is home to a variety of fish species, including walleye, lake trout, and whitefish.