The second-largest city of France is Lyon, which has four letters. Lyon is located in the Auvergne-Rhône-Alpes region in the east-central part of the country. It is the third-most populous city in France, with a population of over 500, 000 people. Lyon is known for its historical and architectural landmarks, as well as its vibrant cultural scene. It is also a major economic hub, with many international companies having their headquarters in the city.