Santa ROSA, California is a city located in Sonoma County, north of San Francisco. It is the largest city in the county and is known for its wine production. Santa CRUZ, California is a coastal city located in Santa CRUZ County, south of San Francisco. It is known for its beaches, redwood forests, and liberal atmosphere. Santa ANA, California is a city located in Orange County, southeast of Los Angeles. It is the county seat and is known for its historic downtown area. Santa CLARA, California is a city located in Santa CLARA County, south of San Francisco. It is home to many high-tech companies and is known for its Mediterranean climate.