Rue the Run is a phrase that is used to express regret or sorrow for something that has happened in the past. The term is often used when someone has made a mistake or done something wrong and wishes they could go back and change it. The crossword solution for this term is ACHE, which is a verb meaning to feel physical or emotional pain or distress. This phrase is often used to describe the feeling of regret or sorrow one experiences when they realize they have made a mistake.