The crossword solution for the term RELEASE FROM A KNOT is UNTIE, which is a five-letter word. To UNTIE a knot means to loosen or undo it, and this can be done by hand or with the help of tools. Untying knots is a common task in many professions, such as sailing, fishing, and even surgery. It is also a useful skill to have in everyday life, as it can be used to free items that are stuck together or to open packages.