The term 'refuse to give up' can be summarized by three crossword solutions: PERSIST (7 letters), tryagain (8 letters), and holdthetowel (12 letters). PERSIST means to continue doing something despite difficulty or opposition. Tryagain implies making an effort to do something again, even if it has been unsuccessful in the past. Holdthetowel is an idiom that means to keep trying, even when things seem hopeless. All three of these solutions suggest that one should not give up, but instead keep trying and pushing forward.