The crossword solution for the term 'REACT TO A WEAK HAND' is PASS. This four-letter word is often used in card games such as poker, where it means to not bet or call a bet, but instead to discard one's hand and wait for the next round. In this context, it can be interpreted as a reaction to a weak hand, meaning that the player has decided to not continue with the current hand due to its lack of strength.