Rattler's Defense is a defensive strategy used by rattlesnakes to ward off predators. It involves the rattlesnake making a loud NOISE and releasing a venomous spray. The two crossword solutions for this term are 'VENOM' and 'NOISE'. VENOM is a toxic substance produced by rattlesnakes that can cause serious injury or even death when injected into a victim. NOISE is the sound made by the rattlesnake's tail as it vibrates, which is used to warn potential predators of its presence.