The crossword solution for the term PRUNE with 'OFF' is LOP. Pruning is a horticultural practice that involves cutting away dead or overgrown branches, buds, and roots from plants and trees. It is done to promote healthy growth and to shape the plant or tree into a desired form. Pruning can also be used to remove diseased or damaged parts of the plant. LOP is a term used to describe the act of pruning, as it involves cutting OFF parts of the plant.