Professor Higgins is a character from the musical My Fair Lady, based on George Bernard Shaw's play Pygmalion. He is a professor of phonetics who takes on the challenge of transforming a Cockney flower girl, Eliza Doolittle, into a proper lady. His name is a combination of two characters from Shaw's play: Professor Henry Higgins and Colonel Pickering. The crossword solution for Professor Higgins is ENRY, which is the first four letters of his last name.