The term 'Prima Donna Problems' refers to the difficulties that can arise when a person, usually in a leadership role, has an inflated sense of self-importance. This is often referred to as having an 'EGO, ' which is the four-letter solution to this crossword puzzle. People with large egos may be difficult to work with, as they may be unwilling to compromise or take advice from others. They may also be overly demanding and expect special treatment. Prima donna problems can lead to tension and conflict in the workplace, making it difficult for teams to work together effectively.