The crossword solution for the term 'PREFIX WITH -PEDIC' is ORTHO, which is a five-letter word. The prefix 'ortho-' is derived from the Greek word 'orthos, ' meaning 'straight, correct, or true.' It is commonly used in medical terminology to refer to straightness or correctness of body parts or functions. The suffix '-pedic' is derived from the Greek word 'podos, ' meaning 'FOOT.' When combined with the prefix 'ortho-, ' it refers to conditions or treatments related to the feet. Therefore, the term 'prefix with -pedic' can be used to describe any medical condition or treatment related to the feet that begins with the prefix 'ortho-.'