The crossword solution for the term 'Prefix with NATAL or CLASSICAL' is NEO, which is a three-letter word. NEO is a prefix that can be used to describe something as new, recent, or modern. It is often used in combination with words such as 'NATAL' or 'CLASSICAL' to indicate a new or modern version of something that has been around for a long time. For example, 'Neo-CLASSICAL' architecture refers to a style of architecture that combines elements of CLASSICAL and modern design.