The term 'Prefix with Metrics' can be solved by two crossword solutions: ECONO (5 letters) and ISO (3 letters). ECONO is a prefix derived from the Greek word oikonomia, meaning 'household management'. It is used to refer to economic activities or policies that are efficient and cost-effective. ISO is an acronym for the International Organization for Standardization, which is an international body that sets standards for products, services, and systems. It is often used as a prefix to refer to metrics related to quality assurance and product safety.