The crossword solutions for the term 'PREFIX WITH 'LOCK' AND 'FREEZE'' is ANTI. The prefix 'ANTI' is used to describe something that is opposed to or against something else. For example, 'LOCK' and 'FREEZE' can be prefixed with 'ANTI' to create 'ANTI-LOCK' and 'ANTI-FREEZE'. ANTI-LOCK brakes are a safety feature in cars that prevents the wheels from locking up when the brakes are applied, while ANTI-FREEZE is a chemical used to lower the freezing point of a liquid, usually water, to prevent it from freezing in cold temperatures.