The crossword solution for the term 'PREFIX WITH FREEZE' is ANTI, which is a four-letter word. The prefix 'ANTI-' is derived from the Greek word 'ANTI, ' meaning 'AGAINST' or 'OPPOSITE.' It is used to form words that express opposition, such as 'ANTIPATHY, ' 'ANTITHESIS, ' and 'antibody.' When combined with the word 'FREEZE, ' it creates the word 'ANTIFREEZE, ' which is a chemical compound used to lower the freezing point of a liquid, allowing it to remain in a liquid state even at low temperatures.