The term 'prefix with fiction' can be solved by two crossword solutions: META (4 letters) and ECO (3 letters). META is a prefix derived from the Greek language meaning 'BEYOND' or 'AFTER'. It is commonly used to refer to something that is an abstraction of something else, such as a meta-analysis which is an analysis of other analyses. ECO is also a prefix derived from the Greek language meaning 'HOME' or 'ENVIRONMENT'. It is often used to refer to something related to the ENVIRONMENT, such as eco-friendly products which are designed to have minimal impact on the ENVIRONMENT.