The crossword solution for the term 'Prefix with Colonialism' is NEO, which is a three-letter word. NEO is a prefix derived from the Greek word neos, meaning 'NEW'. It is often used to describe something that is modern or recently developed, and it is commonly used in conjunction with colonialism. Neo-colonialism is a term used to describe the economic, political, and cultural influence of a former colonial power over a newly independent nation. Neo-colonialism can involve direct control of a nation's resources and economy, as well as indirect control through the use of economic and political pressure.