The crossword solution for the term 'prefix with CLASSIC or NATAL' is NEO, which is a three-letter word. NEO is a prefix that is commonly used in combination with other words to create NEW terms. It is derived from the Greek word 'neos, ' meaning 'NEW.' NEO is often used in combination with words such as 'CLASSIC' or 'NATAL' to create terms such as 'neoclassic' or 'neonatal, ' which refer to something that is NEW or modernized version of a CLASSIC or something related to childbirth.