The term 'Popular Vacation Isle' can be solved by the five-letter word 'ARUBA'. ARUBA is a small island located in the Caribbean Sea, off the coast of Venezuela. It is known for its white sand beaches and crystal clear waters, making it a popular destination for tourists. The island is also home to a variety of activities, from snorkeling and scuba diving to windsurfing and kiteboarding. Additionally, ARUBA is known for its vibrant nightlife and diverse culture.