A point of disagreement is a disagreement between two or more people on a particular ISSUE. It is also known as an ISSUE, which is the 5-letter solution to the crossword. A point of disagreement can be caused by a variety of factors, such as different opinions, values, beliefs, or experiences. It can lead to heated debates and arguments, and can even cause relationships to break down. It is important to be able to recognize and address points of disagreement in order to maintain healthy relationships.