The crossword solution for the term 'Place to De-Stress' is SPA, which stands for 'sanus per aquam, ' which is Latin for 'health through water.' A SPA is a place where people can go to relax and de-stress, often through the use of massage, saunas, steam rooms, and other treatments. Spas are also known for their luxurious atmosphere, making them a popular destination for those looking to escape the stresses of everyday life.