Physical discomfort is a broad term that can refer to a range of physical sensations, from mild to severe. PAIN, ACHE, MALAISE, and UNEASE are all words that can be used to describe physical discomfort. PAIN is a sharp or throbbing sensation that can be localized or widespread. ACHE is a dull, continuous PAIN that is usually localized. MALAISE is a general feeling of UNEASE or discomfort that may be accompanied by physical symptoms such as fatigue or nausea. UNEASE is a feeling of anxiety or apprehension. All of these words can be used to describe physical discomfort.