The term 'Pharmaceutical Giant, Informally' can be answered with the five-letter word 'Lilly'. Eli Lilly and Company is an American pharmaceutical company founded in 1876 by Colonel Eli Lilly. It is one of the world's largest pharmaceutical companies and produces a wide range of prescription drugs, including Prozac, Cialis, and Humalog. The company is headquartered in Indianapolis, Indiana, and has operations in over 60 countries.