Persistent Desire is a term that describes a strong and long-lasting wish or ambition. It is often used to describe a goal that someone is determined to achieve, no matter how difficult it may be. The crossword solution for this term is ITCH, which is a feeling of irritation or discomfort that can be caused by a variety of things, such as an insect bite or an allergy. This term is often used to describe the feeling of wanting something so badly that it becomes almost unbearable. In this case, the ITCH is a metaphor for the persistent desire that someone has to achieve their goal.