The term 'painfully sensitive' can be described by two crossword solutions: 'SORE' (4 letters) and 'TENDER' (6 letters). Soreness is a feeling of discomfort or pain that is usually localized to a specific area of the body. It can be caused by a variety of factors, such as injury, infection, or inflammation. Tenderness is a heightened sensitivity to touch or pressure, which can also be caused by injury, infection, or inflammation. Both soreness and tenderness are common symptoms of many medical conditions and can be indicative of underlying issues.