Pain killers are medications used to reduce or eliminate pain. They can be either over-the-counter or prescription drugs, and they work by blocking the transmission of pain signals from the body to the brain. The two crossword solutions for the term 'pain killer' are 'CURE' and 'achesmurderer'. 'CURE' is a four letter word that refers to the act of healing or restoring health. 'Achesmurderer' is a thirteen letter word that refers to a drug that kills pain.