The crossword solution for the term 'OPRAH' is 'COTTON'. Oprah Winfrey is an American media executive, actress, talk show host, television producer and philanthropist. She is best known for her talk show The Oprah Winfrey Show, which was the highest-rated television program of its kind in history and was nationally syndicated from 1986 to 2011. She is also the founder of the Oprah Winfrey Network. COTTON is a soft, fluffy staple fiber that grows in a boll, or protective case, around the seeds of the COTTON plants of the genus Gossypium in the mallow family Malvaceae. COTTON is one of the world's most important natural fibers and is used to make a variety of textile products.