The term 'OPPOSITE OF A BLESSING' can be answered with the crossword solution 'CURSE', which is a five-letter word. A CURSE is an expression of strong displeasure or hostility, often invoking supernatural powers to bring about misfortune or harm. It is usually seen as a form of punishment or retribution for wrongdoings. Curses are often used in literature and folklore, and are sometimes seen as a way to express anger or frustration.