Once and Again is a phrase that is used to describe something that has happened more than once, but not necessarily in a repetitive manner. It is often used to emphasize the importance of an event or situation that has occurred multiple times. The term can also be used to refer to something that has been done before, but is being done again for a different purpose. In the context of a crossword puzzle, the term 'TWICE' is a five-letter word that can be used to solve the clue 'Once and Again'.