NYC's LEX, E.G. is an abbreviation for Lexington Avenue, a major thoroughfare in New York City. It is one of the longest avenues in Manhattan, running from East 24th Street to the Harlem River Drive at 132nd Street. The avenue is named after the Battle of Lexington, which was fought during the American Revolutionary War. The crossword solution for NYC's LEX, E.G. is AVE, which is short for avenue.