The crossword solution for the term 'Noble Family Italian' is ESTE. The House of Este is an Italian noble family that was founded in the 12th century and is one of the most important families in Italian history. They were originally from the city of Este in the Veneto region of northern Italy and were influential in politics, culture, and the arts. The family has produced several notable members, including Pope Alexander VI, Lucrezia Borgia, and Isabella d'Este.