The crossword solution for the term 'New York City on Lake Ontario' is Oswego. Oswego is a city located in Oswego County, New York, United States, on the shore of Lake Ontario. It is the county seat of Oswego County and the largest city in the county. The city is located about 45 miles north of Syracuse and about 90 miles east of Rochester. Oswego is known for its historic harbor, which was once a major port for shipping grain and other goods. Today, the city is home to a number of businesses, including a large paper mill and a nuclear power plant.