The term MUTATION TARGET can be broken down into two parts: Mutation and Target. Mutation is a process in which the genetic material of a living organism is changed, resulting in a new trait or characteristic. Target refers to the GENE that is affected by the mutation. The crossword solution for the term MUTATION TARGET is GENE, which is an abbreviation for 'genetic material'. GENE is a four-letter word that describes the specific area of the organism that is affected by the mutation.