Muscle woe is a term used to describe a variety of physical ailments related to the muscles. The crossword solutions for this term are STRAIN (6 letters), ACHE (4 letters), SPASM (5 letters), CRAMP (5 letters), and KNOT (4 letters). STRAIN is an injury to a muscle or tendon caused by overstretching or tearing. ACHE is a dull, continuous pain in a muscle or joint. SPASM is an involuntary contraction of a muscle. CRAMP is a sudden, painful tightening of a muscle. KNOT is a tight, hard lump in a muscle caused by tension or stress.