The crossword solutions for the term MOST SENSELESS are INANEST (7 letters) and INSANEST (8 letters). INANEST is an adjective meaning 'utterly foolish or senseless' while INSANEST is an adverb meaning 'in the most foolish or senseless manner'. Both words are derived from the root word 'sensless', which means 'lacking sense or reason'. Therefore, these two words can be used to describe something that is utterly foolish or senseless in the most extreme way.