The term 'most negligible' can be defined as having the LEAST amount of importance or significance. This term can be broken down into two crossword solutions: 'MEREST' (6 letters) and 'LEAST' (5 letters). Both words mean the same thing, but 'MEREST' is a more formal way of saying it. The term 'most negligible' is often used to describe something that is so small or insignificant that it can be overlooked or ignored.